the answer is yes and no. the bottom line is, you can’t do it from a single command line execution as you can generally with other MSI installations.
for example, if you wanted to run the momagent.msi and use the patch switch as shown in this example, it simply will not work.
msiexec /i MOMAgent.msi PATCH=Q954049-x86.msp;Q954903-x86.msp;Q956689-x86.msp USE_SETTINGS_FROM_AD=0 MANAGEMENT_GROUP=mytestgroup MANAGEMENT_SERVER_DNS=mytestserver.mydomain.com SECURE_PORT=5723 ACTIONS_USE_COMPUTER_ACCOUNT=1 /l opsmgr_install.log
instead, you’d have to run the previous installation without specifying the PATCH= switch. once completed, then you can roll in the additional patches by running msiexec in update mode. it would look something like this:
msiexec /update Q954049-x86.msp;Q954903-x86.msp;Q956689-x86.msp REINSTALL=ALL REINSTALLMODE=omus /L*v opsmgr_install.log /qn